Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the YmL27 ribosomal protein family. [provided by RefSeq, Jul 2008]
Function:
Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
Subcellular Location:
Mitochondrion.
Tissue Specificity:
Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).
Similarity:
Belongs to the ribosomal protein L41 family.
SWISS:
Q8IXM3
Gene ID:
64975
Database links:
Entrez Gene: 64975 Human
Entrez Gene: 107733 Mouse
Entrez Gene: 296551 Rat
Omim: 611846 Human
SwissProt: Q8IXM3 Human
SwissProt: Q9CQN7 Mouse
SwissProt: Q5BJX1 Rat
Unigene: 8817 Human
Unigene: 23010 Mouse
Unigene: 92811 Rat
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