Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Subcellular Location:
Mitochondrion.
SWISS:
Q6P161
Gene ID:
116541
Database links:
Entrez Gene: 116541 Human
Entrez Gene: 66047 Mouse
Omim: 611858 Human
SwissProt: Q6P161 Human
SwissProt: Q9CPW3 Mouse
Unigene: 356578 Human
Unigene: 43397 Mouse
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