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Rabbit Anti-MRPS18C antibody
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. Pseudogenes corresponding to this gene are found on chromosomes 8p, 12p, 15q, and 22q. [provided by RefSeq, Jul 2008]
Subunit:
Component of the mitochondrial ribosome small subunit
Subcellular Location:
Mitochondrion.
Similarity:
Belongs to the ribosomal protein S18P family.
SWISS:
Q9Y3D5
Gene ID:
51023
Database links:
Entrez Gene: 51023 Human
Entrez Gene: 68735 Mouse
Entrez Gene: 289469 Rat
Omim: 611983 Human
SwissProt: Q9Y3D5 Human
SwissProt: Q8R2L5 Mouse
Unigene: 334772 Human
Unigene: 436161 Human
Unigene: 25585 Mouse
Unigene: 105741 Rat
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