Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that may be a functional partner of the death associated protein 3 (DAP3). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2013]
Subcellular Location:
Mitochondrion.
Similarity:
Contains 2 PPR (pentatricopeptide) repeats.
SWISS:
Q92552
Gene ID:
23107
Database links:
Entrez Gene: 23107 Human
Entrez Gene: 218506 Mouse
Omim: 611989 Human
SwissProt: Q92552 Human
SwissProt: Q8BK72 Mouse
Unigene: 482491 Human
Unigene: 730225 Human
Unigene: 30208 Mouse
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