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Rabbit Anti-MRPS31 antibody
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13. [provided by RefSeq, Jul 2008]
Subunit:
Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Subcellular Location:
Mitochondrion.
SWISS:
Q92665
Gene ID:
1048
Database links:
Entrez Gene: 1048 Human
Entrez Gene: 57312 Mouse
Entrez Gene: 290850 Rat
Omim: 611992 Human
SwissProt: Q92665 Human
SwissProt: Q61733 Mouse
SwissProt: B0BN56 Rat
Unigene: 596607 Human
Unigene: 289402 Mouse
Unigene: 22173 Rat
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