Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008]
Subcellular Location:
Mitochondrion.
Similarity:
Belongs to the ribosomal protein S5P family.
Contains 1 S5 DRBM domain.
SWISS:
P82675
Gene ID:
64969
Database links:
Entrez Gene: 512469 Cow
Entrez Gene: 475746 Dog
Entrez Gene: 64969 Human
Entrez Gene: 77721 Mouse
Entrez Gene: 296134 Rat
Omim: 611972 Human
SwissProt: Q2KID9 Cow
SwissProt: P82675 Human
SwissProt: Q99N87 Mouse
Unigene: 655259 Human
Unigene: 27921 Mouse
Unigene: 439196 Mouse
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