Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]
Function:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. MRPS6 encodes a 28S subunit protein that belongs to the ribosomal protein S6P family.
Subunit:
Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Subcellular Location:
Mitochondrion
Similarity:
Belongs to the ribosomal protein S6P family.
SWISS:
P82932
Gene ID:
64968
Database links:
Entrez Gene: 615431 Cow
Entrez Gene: 64968 Human
Entrez Gene: 121022 Mouse
Entrez Gene: 288253 Rat
Omim: 611973 Human
SwissProt: P82931 Cow
SwissProt: P82932 Human
SwissProt: P58064 Mouse
Unigene: 302742 Human
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