The termination of protein synthesis is carried out by a variety of auxiliary factors that ensure the proper release of newly formed proteins. Once translation is complete, mRNA and P-site deacylated tRNA remain attached to the ribosome in a post-termination complex (post-TC) that must be dissociated and recycled in order for another round of translation to take place. MRRF (mitochondrial ribosome recycling factor), also known as RRF, MRFF or MTRRF, is a 262 amino acid protein that belongs to the RRF (ribosome recycling factor) family. Localized to mitochondria, MRRF is required for the release of ribosomes from mRNA at the end of protein biosynthesis. Via its ability to recycle ribosomes throughout translation, MRRF may actually increase overall translational efficiency, thereby playing an important role in the rate of protein synthesis. Multiple isoforms of MRRF are expressed due to alternative splicing events.
Function:
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
Subcellular Location:
Mitochondrion.
Similarity:
Belongs to the RRF family.
SWISS:
Q96E11
Gene ID:
92399
Database links:
Entrez Gene: 92399 Human
Entrez Gene: 67871 Mouse
Entrez Gene: 311903 Rat
Omim: 60922 Human
SwissProt: Q96E11 Human
SwissProt: Q9D6S7 Mouse
SwissProt: Q5RKI9 Rat
Unigene: 73611 Human
Unigene: 378232 Mouse
Unigene: 105234 Rat
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