This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Function:
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
Subcellular Location:
Cytoplasm. Associated with polysomes.
Tissue Specificity:
Ubiquitous; detected at low levels.
Post-translational modifications:
Phosphorylated.
DISEASE:
Note=Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).
Similarity:
Belongs to the Musashi family.
Contains 2 RRM (RNA recognition motif) domains.
SWISS:
Q96DH6
Gene ID:
124540
Database links:
Entrez Gene: 124540 Human
Entrez Gene: 76626 Mouse
Entrez Gene: 72596 Rat
Omim: 607897 Human
SwissProt: Q96DH6 Human
SwissProt: Q920Q6 Mouse
Unigene: 658922 Human
Unigene: 400451 Mouse
Unigene: 428433 Mouse
Unigene: 474737 Mouse
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