Rabbit Anti-phospho-MSK2 (Thr568) antibody

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MSK2 / RSK-B (phospho T568); p-MSK2 / RSK-B (phospho T568); 90 kDa ribosomal protein S6 kinase 4; EC 2.7.11.1; KS6A4_HUMAN; Mitogen and stress activated protein kinase 2; Nuclear mitogen and stress activated protein kinase 2; Nuclear mitogen- and str

Cat:

SL17855R

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthesised phosphopeptide derived from human MSK2 around the phosphorylation site of Thr568:MQ(p-T)P

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

WB=1:500-2000ELISA=1:5000-10000not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $256.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Function:
Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. Essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF) and result in the transcriptional activation of several immediate early genes, including proto-oncogenes FOS and JUN (By similarity). Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).

Subcellular Location:
Nucleus.

Similarity:
Belongs to the protein kinase superfamily.
AGC Ser/Thr protein kinase family.
S6 kinase subfamily.
Contains 1 AGSLCkinase SLCterminal domain.
Contains 2 protein kinase domains.

SWISS:
O75676

Gene ID:
8986

Database links:

Entrez Gene: 8986 Human

Entrez Gene: 361715 Rat

Omim: 60726 Human

SwissProt: O75676 Human

Unigene: 105584 Human

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