[email protected]
Home > Product > Antibody > Rabbit Anti-MST1/MST2 antibody
DKFZp686A2068; FLJ90748; KRS1; KRS2; Mammalian STE20 like protein kinase 1; Mammalian STE20 like protein kinase 2; MST 1; MST 2; MST1; MST2; Serine/threonine kinase 3 (STE20 homolog yeast); Serine/threonine kinase 3 (Ste20 yeast homolog); Seri
Cat:
SL8477R
Species Reactivity：
(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Zebrafish,Guinea Pig,Cat,Chimpanzee,Rhesus monkey, Gorilla, Tilapia, Orangutan, Xenopus tropical)
Immunogen：
KLH conjugated synthetic peptide derived from human MST1/MST2
Format：
Liquid
Storage instructions：
Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
More
prev next
Unit:
Price: $
Product PDFs
Datasheet:


This gene encodes a serine/threonine protein kinase activated by proapoptotic molecules indicating the encoded protein functions as a growth suppressor. Cleavage of the protein product by caspase removes the inhibitory SLCterminal portion. The N-terminal portion is transported to the nucleus where it homodimerizes to form the active kinase which promotes the condensation of chromatin during apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Function:
The human serine/threonine kinase, mammalian STE20 like kinase (MST), is considerably homologous to the budding yeast kinases, SPS1 and STE20, throughout their kinase domains. When stably expressed in HeLa cells, MST highly sensitizes the cells to death receptor mediated apoptosis by accelerating caspase 3 activation. These findings suggest that MST1 and MST2 play a role in apoptosis both upstream and downstream of caspase activation. MST1 is cleaved and activated by caspases during apoptosis and is capable of inducing apoptotic morphological changes such as chromatin condensation upon overexpression. Mammalian Sterile 20 Like 2 (MST2) is most similar to the previously identified MST1 protein kinase (78% identity, 88% similarity). Northern analysis indicates that MST2 mRNA is expressed at high levels in adult kidney, skeletal and placental tissues and at very low levels in adult heart, lung, liver and brain tissues. An in vitro kinase assay indicates that MST2 can phosphorylate an exogenous substrate, as well as itself, and phospho amino acid analysis indicates that it is a serine/threonine protein kinase.

Subcellular Location:
Cytoplasm. Nucleus. Note: The caspase cleaved form cycles between the nucleus and cytoplasm.

SWISS:
Q13043

Gene ID:
6788

Database links:

Entrez Gene: 6788 Human

Entrez Gene: 6789 Human

Entrez Gene: 311622 Rat

Entrez Gene: 65189 Rat

Omim: 604965 Human

Omim: 605030 Human

SwissProt: Q13043 Human

SwissProt: Q13188 Human

SwissProt: O54748 Rat



Product Feedback Wall
Message :
Your Email :
Copyright © 2007-2018 Sunlong Medical All Rights Reserved.