Binds to the metal-regulating-element (MRE) of metallothionein gene promoter. May be involved in the activation of MT (metallothionein) genes in response to heavy-metal ions.
Function:
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).
Subunit:
Associated component of the PRC2 complex (By similarity).
Subcellular Location:
Nuclear
Similarity:
Belongs to the Polycomblike family.
Contains 2 PHD-type zinc fingers.
Contains 1 Tudor domain.
SWISS:
Q9Y483
Gene ID:
22823
Database links:
Entrez Gene: 22823 Human
Entrez Gene: 17765 Mouse
Entrez Gene: 72905 Rat
Omim: 609882 Human
SwissProt: Q9Y483 Human
SwissProt: Q02395 Mouse
Unigene: 229278 Rat
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