MTH1 is a 179 amino acid cytoplasmic protein that is a member of the nudix hydrolase family. Highly expressed in testis, thymus and proliferating blood lymphocytes, MTH1 functions as an antimutagenic that hydrolyzes oxidized purine nucleoside triphosphates to their corresponding monophosphates. Through its ability to enzymatically hydrolyze ATP and GTP to AMP and GMP, respectively, MTH1 prevents misincorporation of GTP into DNA, thus preventing A:T to C:G transversions. The cytoplasmic location of MTH1, along with its antimutagenic capabilities, suggests that it may also be involved in the sanitization of nucleotide pools for both mitochondrial and nuclear genomes. Four isoforms of MTH1 exist—three of which are formed due to alternative splicing events and one of which is formed via a single-nucleotide polymorphism. Overexpression of MTH1 is implicated in prostate and cell lung carcinomas
Function:
Mitochondrial GTPase. May be involved in assembly of the large ribosomal subunit.
Subcellular Location:
Mitochondrion.
Similarity:
Belongs to the MMR1/HSR1 GTP-binding protein family. MTG1 subfamily.
Contains 1 G (guanine nucleotide-binding) domain.
SWISS:
Q9BT17
Gene ID:
92170
Database links:
Entrez Gene: 92170 Human
Entrez Gene: 509768 Cow
Entrez Gene: 212508 Mouse
SwissProt: Q4PS77 Cow
SwissProt: Q9BT17 Human
SwissProt: Q8R2R6 Mouse
Unigene: 501578 Human
Unigene: 296088 Mouse
|
|
