This locus represents naturally occurring read-through transcription between the neighboring suppressor of tumorigenicity 20 and 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) genes on chromosome 15. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Dec 2010]
Function:
Contributes to tetrahydrofolate metabolism. Helps regulate carbon flow through the folate-dependent one-carbon metabolic network that supplies carbon for the biosynthesis of purines, thymidine and amino acids.
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
SWISS:
P49914
Gene ID:
100528021
Database links:
Entrez Gene: 513372 Cow
Entrez Gene: 100528021 Human
Entrez Gene: 10588 Human
Entrez Gene: 107885 Mouse
Entrez Gene: 300886 Rat
Omim: 604197 Human
SwissProt: P49914 Human
SwissProt: Q9D110 Mouse
Unigene: 194294 Human
Unigene: 459049 Human
Unigene: 486274 Mouse
Unigene: 2215 Rat
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