Rabbit Anti-mu Crystallin antibody

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CRYM; CRYM_HUMAN; Crystallin mu; DFNA 40; DFNA40; Ketimine reductase; Mu crystallin homolog; Mu-crystallin homolog; NADP regulated thyroid hormone binding protein; NADP-regulated thyroid-hormone-binding protein; OTTHUMP00000115878; THBP; Thiom

Cat:

SL17900R

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Cow,Sheep,Cat,)

Immunogen：

KLH conjugated synthetic peptide derived from human mu Crystallin:231-314/314

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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Crystallins are separated into two classes: taxon-specific and ubiquitous. The former class is also called phylogenetically-restricted crystallins. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases. The encoded protein does not perform a structural role in lens tissue, and instead it binds thyroid hormone for possible regulatory or developmental roles. Mutations in this gene have been associated with autosomal dominant non-syndromic deafness. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]

Function:
Binds thyroid hormone. Presumably involved in the regulation of the free intracellular concentration of triiodothyronine and access to its nuclear receptors.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in neural tissue, muscle and kidney.

Similarity:
Belongs to the ornithine cyclodeaminase family.

SWISS:
Q14894

Gene ID:
1428

Database links:

Entrez Gene: 1428 Human

Entrez Gene: 505167 Cow

Entrez Gene: 12971 Mouse

Entrez Gene: 117024 Rat

Omim: 123740 Human

SwissProt: Q14894 Human

SwissProt: O54983 Mouse

SwissProt: Q9QYU4 Rat

Unigene: 924 Human

Unigene: 9114 Mouse

Unigene: 24561 Rat

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