Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal structure, provide signal transduction, and confer antiadhesive properties upon cancer cells that lose their apical/basal polarization.[supplied by OMIM, Apr 2004]
Function:
Probably plays a role in maintaining homeostasis on mucosal surfaces.
Subcellular Location:
Cell membrane and Secreted. Cell membrane.
Tissue Specificity:
Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in pancreatic adenocarcinoma tissue (at protein level). Expression is not detectable in normal pancreas, in pancreatitis or in cell lines derived from other cancers.
Post-translational modifications:
Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.
Similarity:
Contains 1 EGF-like domain.
Contains 1 SEA domain.
SWISS:
Q685J3
Gene ID:
140453
Database links:
Entrez Gene: 140453 Human
SwissProt: Q685J3 Human
Unigene: 271819 Human
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