This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The SLCterminus of this family member associates with the multifunctional docking site of the MET proto-oncogene and suppresses activation of some downstream MET signaling cascades. The protein features a mucin tandem repeat domain that varies between two and six copies in most individuals. Multiple variants encoding different isoforms have been found for this gene. A related pseudogene, which is also located on chromosome 3, has been identified. [provided by RefSeq, Apr 2014]
Function:
May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression.
Subunit:
Interacts with MET; oligomerization increases affinity for MET.
Subcellular Location:
Secreted. Apical cell membrane. Basolateral cell membrane. Cell projection > microvillus membrane.
Tissue Specificity:
Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with the exception of epididymis.
SWISS:
Q8N307
Gene ID:
200958
Database links:
Entrez Gene: 200958 Human
Entrez Gene: 224116 Mouse
Omim: 61072 Human
SwissProt: Q8N307 Human
SwissProt: Q8BUE7 Mouse
Unigene: 308992 Human
Unigene: 153301 Mouse
Unigene: 484124 Mouse
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