The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the ORC4 family.
SWISS:
O43929
Gene ID:
5000
Database links:
Entrez Gene: 5000 Human
Entrez Gene: 529245 Cow
Entrez Gene: 26428 Mouse
Entrez Gene: 295596 Rat
Omim: 603056 Human
SwissProt: Q2YDI2 Cow
SwissProt: O43929 Human
SwissProt: O88708 Mouse
SwissProt: Q6P9Z8 Rat
Unigene: 558364 Human
Unigene: 291059 Mouse
Unigene: 314338 Mouse
Unigene: 144844 Rat
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