The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]
Function:
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the ORC5 family.
SWISS:
O43913
Gene ID:
5001
Database links:
Entrez Gene: 5001 Human
Entrez Gene: 26429 Mouse
Entrez Gene: 362304 Rat
Omim: 602331 Human
SwissProt: O43913 Human
SwissProt: Q9WUV0 Mouse
Unigene: 432948 Human
Unigene: 412217 Mouse
Unigene: 474058 Mouse
Unigene: 137519 Rat
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