Rabbit Anti-ORMDL1 + ORMDL2 + ORMDL3 antibody

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Cat:

SL3635R

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human ORMDL1 + ORMDL2 + ORMDL3:1-80/153

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3; all of which are human homologs of the S. cerevisiae ORM1 protein. Localized to the membrane of the endoplasmic reticulum, ORMDLs are multi-pass membrane proteins that are implicated in ?secretase (BACE) function, as well as expression of Presenilin (PSI), a protein involved in Alzheimer抯 disease (AD). ORMDL1 (ORM1-like protein 1), also known as Adoplin-1, is a widely expressed 153 amino acid member of the ORMDL family. Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDL2 (ORM1-like protein 2), also known as Adoplin-2, and ORMDL3 (ORM1-like protein 3) are expressed in tissues such as heart, brain, lung, liver and kidney. ORMDL3 exists as two isoforms due to alternative splicing events and may be a determinant of susceptibility to childhood asthma

SWISS:
Q9P0S3, Q53FV1, Q8N138

Gene ID:
94101

Database links:

Entrez Gene: 94101 Human

SwissProt: Q9P0S3 Human

SwissProt: Q53FV1 Human

SwissProt: Q8N138 Human

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