Rabbit Anti-HLA-DQB2 antibody

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DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB)); DX-beta; HLA class II histocompatibility antigen, DQ beta 2 chain; HLA class II histocompatibility antigen, DX beta chain; HLA DQB1; HLA DXB; major histocompatibility complex,

Cat:

SL3640R

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human HLA-DQB2:1-100/268<Extracellular>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus. [provided by RefSeq, Oct 2010]

Function:
Belongs to the MHC class II family. Contains one Ig like C1 type (immunoglobulin like) domain.

Subcellular Location:
Cell membrane; Single pass type I membrane protein

Tissue Specificity:
Restricted to skin Langerhans cells (at protein level).

Similarity:
Belongs to the MHC class II family. Contains 1 Ig-like C1-type (immunoglobulin-like)domain.

SWISS:
P05538

Gene ID:
3120

Database links:

Entrez Gene: 3120 Human

Omim: 615161 Human

SwissProt: P05538 Human

Unigene: 731563 Human

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