This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Function:
Highly expressed in liver; lower levels in lung and kidney.
Subcellular Location:
Nucleus.
DISEASE:
Note=A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3.
Similarity:
Belongs to the bZIP family. PAR subfamily.
Contains 1 bZIP domain.
SWISS:
Q16534
Gene ID:
3131
Database links:
Entrez Gene: 3131 Human
Entrez Gene: 217082 Mouse
Entrez Gene: 363667 Rat
Omim: 142385 Human
SwissProt: Q16534 Human
SwissProt: Q8BW74 Mouse
SwissProt: Q64709 Rat
Unigene: 196952 Human
Unigene: 158903 Mouse
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