This gene encodes a metalloenzyme that catalyzes the last step in the conversion of lysine to the unique amino acid hypusine in eukaryotic initiation factor 5A. The encoded protein hydroxylates deoxyhypusine to form hypusine in the mature eukaryotic initiation factor 5A protein. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2009]
Function:
Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
Similarity:
Belongs to the deoxyhypusine hydroxylase family.
Contains 5 HEAT-like PBS-type repeats.
SWISS:
Q9BU89
Gene ID:
83475
Database links:
Entrez Gene: 43740 Fruit fly (Drosophila melanogaster)
Entrez Gene: 83475 Human
Entrez Gene: 102115 Mouse
Entrez Gene: 314644 Rat
Entrez Gene: 321732 Zebrafish
Omim: 611262 Human
SwissProt: Q9V9U4 Fruit fly (Drosophila melanogaster)
SwissProt: Q9BU89 Human
SwissProt: Q99LN9 Mouse
SwissProt: Q5PPJ4 Rat
SwissProt: Q7ZUX6 Zebrafish
Unigene: 29814 Fruit fly (Drosophila melanogaster)
Unigene: 37858 Fruit fly (Drosophila melanogaster)
Unigene: 515064 Human
Unigene: 609012 Human
Unigene: 294975 Mouse
Unigene: 38296 Rat
Unigene: 2393 Zebrafish
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