This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]
Function:
DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS).
Subcellular Location:
Nucleus. Chromosome.
Similarity:
Belongs to the HMGB family.
Contains 2 HMG box DNA-binding domains.
SWISS:
P26583
Gene ID:
3148
Database links:
Entrez Gene: 3148 Human
Entrez Gene: 540444 Cow
Entrez Gene: 97165 Mouse
SwissProt: P40673 Cow
SwissProt: P26583 Human
SwissProt: P30681 Mouse
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