This gene encodes a transcription factor that belongs to the H6 family of homeobox proteins. This protein can bind a 5'-CAAG-3' core DNA sequence, and it is involved in the development of craniofacial structures. Mutations in this gene cause oculoauricular syndrome, a disorder of the eye and external ear. [provided by RefSeq, Oct 2009]
Function:
HMX1 acts as a transcriptional antagonist. It is part of the Hmx family of homeodomain proteins which are predominately expressed in discrete regions of developing sensory tissues.
Subcellular Location:
Nuclear
Similarity:
Belongs to the HMX homeobox family.
Contains 1 homeobox DNA-binding domain.
SWISS:
Q9NP08
Gene ID:
3166
Database links:
Entrez Gene: 396546 Chicken
Entrez Gene: 3166 Human
Entrez Gene: 15371 Mouse
Entrez Gene: 72960 Rat
Omim: 142992 Human
SwissProt: Q9DE09 Chicken
SwissProt: Q9NP08 Human
SwissProt: O70218 Mouse
Unigene: 104134 Human
Unigene: 358606 Mouse
Unigene: 24574 Rat
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Sample:
Lane 1: Mouse Cerebrum tissue lysates
Lane 2: Mouse Cerebellum tissue lysates
Lane 3: Mouse Spinal cord tissue lysates
Lane 4: Mouse Testis tissue lysates
Lane 5: Rat Cerebrum tissue lysates
Lane 6: Rat Cerebellum tissue lysates
Lane 7: Rat Spinal cord tissue lysates
Lane 8: Rat Testis tissue lysates
Primary: Anti-HMX1 (SL3659R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 36 kDa
Observed band size: 48 kDa
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