This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]
Function:
In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
Tissue Specificity:
Expressed in spermatids.
Similarity:
Belongs to the heat shock protein 70 family.
SWISS:
P34931
Gene ID:
3305
Database links:
Entrez Gene: 540190 Cow
Entrez Gene: 3305 Human
Entrez Gene: 15482 Mouse
Entrez Gene: 100144518 Pig
Entrez Gene: 24963 Rat
Entrez Gene: 779883 Xenopus tropicalis
Omim: 140559 Human
SwissProt: P0CB32 Cow
SwissProt: P34931 Human
SwissProt: P16627 Mouse
SwissProt: A5A8V7 Pig
SwissProt: P55063 Rat
Unigene: 690634 Human
Unigene: 14287 Mouse
Unigene: 187184 Rat
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