The heat shock proteins (HSPs) comprise a group of highly conserved, abundantly expressed proteins with diverse functions, which include the assembly and sequestering of multiprotein complexes, transportation of nascent polypeptide chains across cellular membranes and regulation of protein folding. Heat shock proteins (also known as molecular chaperones) fall into six general families: HSP 90, HSP 70, HSP 60, the low molecular weight HSPs, the immunophilins and the HSP 110 family. The HSP 110 family (also known as the HSP 105 family) is composed of HSP 105, Apg-1 and Apg-2.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Similarity:
Belongs to the heat shock protein 70 family.
SWISS:
P34932
Gene ID:
3308
Database links:
Entrez Gene: 3308 Human
Entrez Gene: 15525 Mouse
Entrez Gene: 266759 Rat
GenBank: NM_002154.3 Human
Omim: 601113 Human
SwissProt: Q2TFN9 Dog
SwissProt: P34932 Human
SwissProt: Q61316 Mouse
SwissProt: O88600 Rat
Unigene: 90093 Human
Unigene: 239865 Mouse
Unigene: 163092 Rat
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