Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Subcellular Location:
Nucleus > nucleolus. Localizes at rDNA locus.
Similarity:
Belongs to the methyltransferase superfamily. RRP8 family.
SWISS:
O43159
Gene ID:
23378
Database links:
Entrez Gene: 23378 Human
Entrez Gene: 540208 Cow
Entrez Gene: 476835 Dog
Entrez Gene: 100070052 Horse
Entrez Gene: 101867 Mouse
Entrez Gene: 100623550 Pig
Entrez Gene: 100355346 Rabbit
SwissProt: O43159 Human
SwissProt: Q9DB85 Mouse
Unigene: 652255 Human
Unigene: 231400 Mouse
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