This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Function:
Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.
Subcellular Location:
Membrane.
Tissue Specificity:
Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen.
Similarity:
Belongs to the hydrogen channel family.
SWISS:
Q96D96
Gene ID:
84329
Database links:
Entrez Gene: 84329 Human
Entrez Gene: 74096 Mouse
Omim: 611227 Human
SwissProt: Q96D96 Human
SwissProt: Q3U2S8 Mouse
Unigene: 211511 Human
Unigene: 334637 Human
Unigene: 21764 Mouse
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