Rabbit Anti-ICEBERG antibody

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CAR18_HUMAN; CARD18; Caspase 1 inhibitor Iceberg; Caspase recruitment domain family member 18; Caspase recruitment domain-containing protein 18; Caspase-1 inhibitor Iceberg; ICEBERG caspase 1 inhibitor; Pseudo ICE; UNQ5804; UNQ5804/PRO19611.

Cat:

SL18119R

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human ICEBERG:31-80/90

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ELISA=1:5000-10000IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $228.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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ICEBERG is a member of the death-domain-fold superfamily that is induced by proinflammatory stimuli. Primarily expressed in the heart and placenta, ICEBERG inhibits the generation of IL-1 β which blocks apoptosis during an inflammatory stimulus. ICEBERG inhibits IL-1 beta by associating with caspase-1, thereby preventing caspase-1 from interacting with the pro-apoptotic protein RIP2. The association of ICEBERG with caspase-1 is facilitated by the charge-charge interactions between the prodomain of caspase-1 and the surface charge of ICEBERG. The association of caspase-1 with RIP2 will inhibit apoptosis by generating IL-1 beta. However, the association of caspase-1, which serves both pro and antiapoptotic roles, with ICEBERG induces apoptosis by inhibiting the generation of IL-1 β.

Function:
Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.

Subunit:
Interacts with pro-CASP1. Interacts with CARD8.

Tissue Specificity:
Primarily expressed in the heart and placenta.

Similarity:
Contains 1 CARD domain.

SWISS:
P57730

Gene ID:
59082

Database links:

Entrez Gene: 59082 Human

Omim: 605354 Human

SwissProt: P57730 Human

Unigene: 56279 Human

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