Rabbit Anti-phospho-IL10RA (Ser319 + Ser323) antibody

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IL10RA (phospho S319 + S323); p-IL10RA (phospho S319 + S323); CD210; CDw210a; CDw210a antigen; HIL 10R; HIL10R; I10R1_HUMAN; IL 10R 1; IL 10R A; IL 10R; IL 10R1; IL-10 receptor subunit alpha; IL-10R subunit 1; IL-10R subunit alpha; IL-10R1;

Cat:

SL18131R

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated Synthesised phosphopeptide derived from human IL10RA around the phosphorylation site of Ser319 + Ser323:TD(p-S)GFG(p-S)TK<Cytoplasmic>

Format：

Liquid

Storage instructions：

Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

IHC-P=1:100-500IHC-F=1:100-500ICC=1:100-500IF=1:100-500（Paraffin sections need to do antigen repair）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

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Unit:

Price: $256.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]

Function:
Receptor for IL10; binds IL10 with a high affinity.

Subcellular Location:
Membrane.

Tissue Specificity:
Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.

DISEASE:
Inflammatory bowel disease 28

Similarity:
Belongs to the type II cytokine receptor family.

SWISS:
Q13651

Gene ID:
3587

Database links:

Entrez Gene: 3587 Human

Omim: 146933 Human

SwissProt: Q13651 Human

Unigene: 504035 Human

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