The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Function:
Binds soluble IL-1 receptor type 1.
Subcellular Location:
Secreted.
Tissue Specificity:
Expressed in fetal skin, spleen and tonsil. Expressed mostly in the basal epithelia of skin and in proliferating B-cells of the tonsil.
Similarity:
Belongs to the IL-1 family.
SWISS:
Q8WWZ1
Gene ID:
84639
Database links:
Entrez Gene: 84639 Human
Entrez Gene: 215274 Mouse
Entrez Gene: 362077 Rat
Omim: 615296 Human
SwissProt: Q8WWZ1 Human
SwissProt: Q8R459 Mouse
Unigene: 306974 Human
Unigene: 218750 Mouse
Unigene: 84164 Rat
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