The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Function:
IL28RA is a class II cytokine receptor that interacts with IL10RB to bind IL28A, IL28B, and IL29, which are related to type I interferons. These ligands play a critical role in response to microbial challenge and activate the JAK/STAT signaling system. It heterodimers with IL10RB. There are 4 isoforms as result of alternative splicing. It is widely expressed. IL28RA belongs to the type II cytokine receptor family, and contains 1 fibronectin type III domain.
Subunit:
Heterodimer with IL10RB.
Subcellular Location:
Membrane; Single-pass type I membrane protein
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the type II cytokine receptor family.
Contains 1 fibronectin type-III domain.
SWISS:
Q8IU57
Gene ID:
163702
Database links:
Entrez Gene: 163702 Human
Entrez Gene: 362628 Rat
Omim: 607404 Human
SwissProt: Q8IU57 Human
Unigene: 221375 Human
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