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Rabbit Anti-IL-1 delta/IL36RN antibody
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Function:
Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
Subcellular Location:
Secreted.
Tissue Specificity:
Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional psoriasis skin.
DISEASE:
Defects in IL36RN are the cause of psoriasis generalized pustular (PSORP) [MIM:614204]. PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of SLCreactive protein.
Similarity:
Belongs to the IL-1 family.
SWISS:
Q9USH0
Gene ID:
26525
Database links:
Entrez Gene: 518514 Cow
Entrez Gene: 26525 Human
Entrez Gene: 54450 Mouse
Entrez Gene: 311783 Rat
Omim: 605507 Human
SwissProt: Q9USH0 Human
SwissProt: Q9QYY1 Mouse
Unigene: 516301 Human
Unigene: 29261 Mouse
Unigene: 63170 Rat
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