The protein encoded by this gene is a nuclear import receptor for serine/arginine-rich (SR) proteins such as the splicing factors SFRS1 and SFRS2. The encoded protein has also been shown to be involved in HISLV1 infection, apparently through interaction with the HISLV1 capsid protein. Two transcript variants encoding different isoforms as well as a noncoding transcript have been found for this gene.[provided by RefSeq, Jul 2010]
Function:
Seems to function in nuclear protein import as nuclear transport receptor. In vitro, mediates the nuclear import of splicing factor SR proteins SFRS1 and SFRS2, by recognizing phosphorylated RS domains.
Subunit:
Interacts with phosphorylated SFRS1 and SFRS2. Interacts with NUP62 and RBM4.
Subcellular Location:
Cytoplasm. Nucleus.
SWISS:
Q9Y5L0
Gene ID:
23534
Database links:
Entrez Gene: 23534 Human
Entrez Gene: 64938 Mouse
Omim: 610032 Human
SwissProt: Q9Y5L0 Human
SwissProt: Q6P2B1 Mouse
Unigene: 193613 Human
Unigene: 276381 Mouse
Unigene: 304472 Mouse
Unigene: 352219 Mouse
Unigene: 424508 Mouse
Unigene: 429470 Mouse
Unigene: 439108 Mouse
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