Predicted to enable actin binding activity. Involved in protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Nov 2021]
Function:
May be involved in cell migration, cartilage development and in linking signal transduction pathways to the cytoskeleton (By similarity). May promote apoptosis, via its cleavage by caspase-3.
Subcellular Location:
Cell junction > focal adhesion. Cytoplasm > cytoskeleton.
Tissue Specificity:
Prostate and placenta. Down regulated in prostate cancer.
Post-translational modifications:
Proteolytically cleaved by caspase-3 during apoptosis.
Similarity:
Contains 1 phosphatase tensin-type domain.
Contains 1 SH2 domain.
SWISS:
Q8IZW8
Gene ID:
84951
Database links:
Entrez Gene: 84951 Human
Entrez Gene: 217169 Mouse
Omim: 608385 Human
SwissProt: Q8IZW8 Human
SwissProt: Q8BZ33 Mouse
Unigene: 438292 Human
Unigene: 262067 Mouse
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