TOE1 is a 510 amino acid long protein that belongs to the CAF1 family. It is a downstream target of EGR-1 and plays an important role mediating the inhibitory growth effect of EGR-1. EGR-1 directly binds the TOE1 promoter region and activates its expression. TOE1 induces the expression of TGF∫ and p21 and plays a role in cell cycle regulation and the inhibition of cell growth. The activity and nucleolar localization of TOE1 correlates with a G2 cell cycle phase delay which is likely due to an increased expression of p21. In addition, TOE1 may function via an interaction with p53 and possible modification to its activity. TOE1 is expressed at various levels in all adult tissues and specifically localizes to the nuclear speckles.
Function:
Inhibits cell growth rate and cell cycle. Induces CDKN1A expression as well as TGF-beta expression. Mediates the inhibitory growth effect of EGR1.
Subcellular Location:
Nucleus > nucleolus. Nucleus speckle. Localizes to nuclear speckles.
Similarity:
Belongs to the CAF1 family.
Contains 1 C3H1-type zinc finger.
SWISS:
Q96GM8
Gene ID:
114034
Database links:
Entrez Gene: 114034 Human
Entrez Gene: 68276 Mouse
Entrez Gene: 298443 Rat
Omim: 613931 Human
SwissProt: Q96GM8 Human
SwissProt: Q9D2E2 Mouse
Unigene: 525091 Human
Unigene: 30534 Mouse
Unigene: 105772 Rat
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