Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]
Function:
Cytokine that promotes the differentiation and viability of monocytes and macrophages. Stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Ligand for colony-stimulating factor-1 receptor CSF1R.
Subcellular Location:
Secreted.
Tissue Specificity:
Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.
Similarity:
Belongs to the IL-34 family.
SWISS:
Q8R1R4
Gene ID:
146433
Database links:
Entrez Gene: 146433 Human
Entrez Gene: 76527 Mouse
Entrez Gene: 498951 Rat
Omim: 612081 Human
SwissProt: Q6ZMJ4 Human
SwissProt: Q8R1R4 Mouse
SwissProt: Q4KM46 Rat
Unigene: 461214 Human
Unigene: 77697 Mouse
Unigene: 16799 Rat
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