INTS10 is a subunit of the Integrator complex, which associates with the SLCterminal domain of RNA polymerase II large subunit (POLR2A; MIM 36660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 36136) and U2 (RNU2; MIM 36690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Function:
INTS10 is a subunit of the Integrator complex, which associates with the SLCterminal domain of RNA polymerase II large subunit and mediates 3-prime end processing of small nuclear RNAs U1.
Subunit:
Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Interacts with POLR2A.
Subcellular Location:
Nuclear
Similarity:
Belongs to the Integrator subunit 10 family.
SWISS:
Q9NVR2
Gene ID:
55174
Database links:
Entrez Gene: 55174 Human
Entrez Gene: 422489 Chicken
Entrez Gene: 534094 Cow
Entrez Gene: 70885 Mouse
Entrez Gene: 290679 Rat
Entrez Gene: 70548 Rhesus monkey
Omim: 611353 Human
SwissProt: Q5ZLS8 Chicken
SwissProt: Q4R7B1 Cynomolgus Monkey
SwissProt: Q9NVR2 Human
SwissProt: Q8K2A7 Mouse
Unigene: 512627 Human
Unigene: 252421 Mouse
Unigene: 2385 Rat
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