INTS4 is a subunit of the Integrator complex, which associates with the SLCterminal domain of RNA polymerase II large subunit (POLR2A; MIM 36660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 36136) and U2 (RNU2; MIM 36690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Function:
Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the SLCterminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Integrator subunit 4 family.
Contains 8 HEAT repeats.
SWISS:
Q96HW7
Gene ID:
92105
Database links:
Entrez Gene: 100712822 Guinea pig
Entrez Gene: 92105 Human
Entrez Gene: 101861 Mouse
Entrez Gene: 10052405 Pig
Entrez Gene: 100350308 Rabbit
Entrez Gene: 308837 Rat
Omim: 611348 Human
SwissProt: Q96HW7 Human
SwissProt: Q8CIM8 Mouse
Unigene: 533723 Human
Unigene: 27383 Mouse
Unigene: 1948 Rat
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