The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW). [provided by RefSeq, Jul 2008]
Function:
Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.
Similarity:
Belongs to the methyltransferase superfamily. LCMT family.
SWISS:
O60294
Gene ID:
9836
Database links:
Entrez Gene: 9836 Human
Entrez Gene: 296098 Rat
Omim: 611246 Human
SwissProt: O60294 Human
SwissProt: Q5XIA3 Rat
Unigene: 200596 Human
Unigene: 533913 Human
Unigene: 741946 Human
Unigene: 17983 Rat
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