LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]
Function:
May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous.
Similarity:
Contains 1 HTH psq-type DNA-binding domain.
SWISS:
Q96JN0
Gene ID:
84458
Database links:
Entrez Gene: 84458 Human
Entrez Gene: 212391 Mouse
Entrez Gene: 365462 Rat
Omim: 607698 Human
SwissProt: Q96JN0 Human
SwissProt: Q6ZPI3 Mouse
Unigene: 729136 Human
Unigene: 398778 Mouse
Unigene: 422910 Mouse
Unigene: 459119 Mouse
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