This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (SLCC motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]
Function:
Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HISLV1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HISLV1-infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5.
Subcellular Location:
Secreted.
Post-translational modifications:
The N-terminal processed forms LD78-beta(3-70) and LD78-beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78-beta(3-70) is probably achieved by DPP4.
Similarity:
Belongs to the intercrine beta (chemokine CC) family.
SWISS:
P16619
Gene ID:
414062
Database links:
Entrez Gene: 414062 Human
Entrez Gene: 6349 Human
Omim: 601395 Human
Omim: 609468 Human
SwissProt: P16619 Human
Unigene: 512304 Human
Unigene: 512683 Human
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