LDLRAD1 is a 205 amino acid protein that belongs to the LDLR family and contains three LDL-receptor class A domains. Existing as three alternatively spliced isoforms, LCLRAD1 is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
Function:
LDLRAD1 is a member of the LDLR family of receptors and has three named isoforms.
Subcellular Location:
Cell Membrane; Single pass membrane protein
SWISS:
Q5T700
Gene ID:
388633
Database links:
Entrez Gene: 388633 Human
SwissProt: Q5T700 Human
Unigene: 439583 Human
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