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Rabbit Anti-LEPROTL1 antibody
Mutation of Ob (Obesity factor), also known as leptin precursor, results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The Ob gene product may function as a component of a signaling pathway in adipose tissue that functions to regulate body fat depot size. The leptin receptor, designated Ob-R, has been shown to be a single membrane-spanning receptor that most resembles the gp130 signal transducing component of the IL-6, G-CSF and LIF receptor. LEPROTL1 (Leptin receptor overlapping transcript-like 1) is a 131 amino acid multi-pass membrane protein that is highly homologous to the leptin receptor gene-related protein, Ob-R. LEPROTL1 is widely expressed and contains a JAK binding site. The LEPROTL1 gene is located on chromosome 8, which is made up of nearly 146 million bases and encodes about 800 genes.
Function:
Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
Subcellular Location:
Membrane.
Tissue Specificity:
Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.
Similarity:
Belongs to the OB-RGRP/VPS55 family.
SWISS:
O95214
Gene ID:
23484
Database links:
Entrez Gene: 23484 Human
Entrez Gene: 68192 Mouse
Entrez Gene: 361160 Rat
Omim: 607338 Human
SwissProt: O95214 Human
SwissProt: Q9CQ74 Mouse
Unigene: 146585 Human
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