The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Function:
Transcription factor involved in differentiation of certain neurons and mesenchymal cells.
Subcellular Location:
Nucleus.
Similarity:
Contains 1 homeobox DNA-binding domain.
Contains 2 LIM zinc-binding domains.
SWISS:
Q68G74
Gene ID:
431707
Database links:
Entrez Gene: 431707 Human
Entrez Gene: 424721 Chicken
Entrez Gene: 16875 Mouse
Entrez Gene: 100310798 Pig
Entrez Gene: 365963 Rat
Entrez Gene: 379649 Xenopus laevis
Entrez Gene: 378959 Zebrafish
Omim: 604425 Human
SwissProt: Q68G74 Human
SwissProt: O35652 Mouse
SwissProt: Q3TMT2 Mouse
Unigene: 403934 Human
Unigene: 15530 Mouse
Unigene: 133072 Rat
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