This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Function:
LHX9 encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine rich zinc binding LIM domains involved in protein protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development.
Subcellular Location:
Nuclear
SWISS:
Q9NQ69
Gene ID:
56956
Database links:
Entrez Gene: 396397 Chicken
Entrez Gene: 515012 Cow
Entrez Gene: 56956 Human
Entrez Gene: 16876 Mouse
Entrez Gene: 397597 Pig
Entrez Gene: 289048 Rat
Entrez Gene: 550405 Zebrafish
Entrez Gene: 572797 Zebrafish
Omim: 606066 Human
SwissProt: Q58CW3 Cow
SwissProt: Q5VUE2 Human
SwissProt: Q5VUE6 Human
SwissProt: Q86UH2 Human
SwissProt: Q9NQ69 Human
SwissProt: Q6GQU4 Mouse
SwissProt: Q9WUH2 Mouse
SwissProt: Q80W90 Rat
SwissProt: Q3LHM3 Zebrafish
Unigene: 442578 Human
Unigene: 250732 Mouse
Unigene: 383589 Mouse
Unigene: 75111 Rat
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