Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]
Subcellular Location:
Cell membrane. Endoplasmic reticulum membrane. Microsome membrane. Mainly found in endoplasmic reticulum but a minority is found on the cell surface.
Similarity:
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
SWISS:
Q9BX59
Gene ID:
55080
Database links:
Entrez Gene: 55080 Human
Entrez Gene: 213233 Mouse
Entrez Gene: 297602 Rat
Omim: 607081 Human
SwissProt: Q9BX59 Human
SwissProt: Q8VD31 Mouse
Unigene: 504597 Human
Unigene: 296902 Mouse
Unigene: 162788 Rat
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