The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]
Function:
Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle.
Subcellular Location:
Nucleus. Localizes to nuclear foci and colocalizes with RAD51.
Tissue Specificity:
Highest levels in placenta, lung and pancreas. Low levels in skeletal muscle and kidney. Expressed in various tumors with highest levels in colon and lung cancers.
Similarity:
Belongs to the MCM family.
Contains 1 MCM domain.
SWISS:
Q9UJA3
Gene ID:
84515
Database links:
Entrez Gene: 421314 Chicken
Entrez Gene: 507507 Cow
Entrez Gene: 477163 Dog
Entrez Gene: 100065561 Horse
Entrez Gene: 84515 Human
Entrez Gene: 66634 Mouse
Entrez Gene: 296178 Rat
Omim: 608187 Human
SwissProt: Q9UJA3 Human
SwissProt: Q9CWV1 Mouse
SwissProt: D3ZVK1 Rat
Unigene: 597484 Human
Unigene: 157070 Mouse
Unigene: 70183 Rat
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