This gene encodes a putative peroxisomal protein that appears to be conserved across Euteleostomi. In humans, it may be autoantigenic. [provided by RefSeq, Jul 2010]
Function:
Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity).
Subunit:
Interacts with LIMK2.
Subcellular Location:
Peroxisome.
Similarity:
Contains 1 RRM (RNA recognition motif) domain.
SWISS:
Q9Y4F3
Gene ID:
9665
Database links:
Entrez Gene: 9665 Human
Entrez Gene: 223989 Mouse
Omim: 614593 Human
SwissProt: Q9Y4F3 Human
SwissProt: Q8BJ34 Mouse
Unigene: 173524 Human
Unigene: 85442 Mouse
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